5,064 research outputs found
Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters
Spinocerebellar ataxia type 2 (SCA2) is a rare neurodegenerative disorder caused by a CAG repeat expansion in the ataxin-2 gene. We show increased oxidative stress, abnormalities in the antioxidant system, changes in complexes involved in oxidative phosphorylation and changes in mitochondrial morphology in SCA2 patient fibroblasts compared to controls, and we show that treatment with CoQ10 can partially reverse these changes. Together, our results suggest that oxidative stress and mitochondrial dysfunction may be contributory factors to the pathophysiology of SCA2 and that therapeutic strategies involving manipulation of the antioxidant system could prove to be of clinical benefit
Sustainable bioethanol production combining biorefinery principles using combined raw materials from wheat undersown with clover-grass
To obtain the best possible net energy balance of the bioethanol production the biomass raw materials used need to be produced with limited use of non-renewable fossil fuels. Intercropping strategies are known to maximize growth and productivity by including more than one species in the crop stand, very often with legumes as one of the components. In the present study clover-grass is undersown in a traditional wheat crop. Thereby, it is possible to increase input of symbiotic fixation of atmospheric nitrogen into the cropping systems and reduce the need for fertilizer applications. Furthermore, when using such wheat and clover-grass mixtures as raw material, addition of urea and other fermentation nutrients produced from fossil fuels can be reduced in the whole ethanol manufacturing chain. Using second generation ethanol technology mixtures of relative proportions of wheat straw and clover-grass (15:85, 50:50, and 85:15) were pretreated by wet oxidation. The results showed that supplementing wheat straw with clover-grass had a positive effect on the ethanol yield in simultaneous saccharification and fermentation experiments, and the effect was more pronounced in inhibitory substrates. The highest ethanol yield (80% of theoretical) was obtained in the experiment with high fraction (85%) of clover-grass. In order to improve the sugar recovery of clover-grass, it should be separated into a green juice (containing free sugars, fructan, amino acids, vitamins and soluble minerals) for direct fermentation and a fibre pulp for pretreatment together with wheat straw. Based on the obtained results a decentralized biorefinery concept for production of biofuel is suggested emphasizing sustainability, localness, and recycling principle
Generating reversible circuits from higher-order functional programs
Boolean reversible circuits are boolean circuits made of reversible
elementary gates. Despite their constrained form, they can simulate any boolean
function. The synthesis and validation of a reversible circuit simulating a
given function is a difficult problem. In 1973, Bennett proposed to generate
reversible circuits from traces of execution of Turing machines. In this paper,
we propose a novel presentation of this approach, adapted to higher-order
programs. Starting with a PCF-like language, we use a monadic representation of
the trace of execution to turn a regular boolean program into a
circuit-generating code. We show that a circuit traced out of a program
computes the same boolean function as the original program. This technique has
been successfully applied to generate large oracles with the quantum
programming language Quipper.Comment: 21 pages. A shorter preprint has been accepted for publication in the
Proceedings of Reversible Computation 2016. The final publication is
available at http://link.springer.co
Random qubit-states and how best to measure them
We consider the problem of measuring a single qubit, known to have been prepared in either a randomly selected pure state or a randomly selected real pure state. We seek the measurements that provide either the best estimate of the state prepared or maximise the accessible information. Surprisingly, any sensible measurement turns out to be optimal. We discuss the application of these ideas to multiple qubits and higher-dimensional systems
Thermodynamic Properties of the Piecewise Uniform String
The thermodynamic free energy F is calculated for a gas whose particles are
the quantum excitations of a piecewise uniform bosonic string. The string
consists of two parts of length L_I and L_II, endowed with different tensions
and mass densities, adjusted in such a way that the velocity of sound always
equals the velocity of light. The explicit calculation is done under the
restrictive condition that the tension ratio x = T_I/T_II approaches zero.
Also, the length ratio s = L_II/L_I is assumed to be an integer. The expression
for F is given on an integral form, in which s is present as a parameter. For
large values of s, the Hagedorn temperature becomes proportional to the square
root of s.Comment: 32 pages, latex, no figure
Scaling Separability Criterion: Application To Gaussian States
We introduce examples of three- and four-mode entangled Gaussian mixed states
that are not detected by the scaling and Peres-Horodecki separability criteria.
The presented modification of the scaling criterion resolves this problem. Also
it is shown that the new criterion reproduces the main features of the scaling
pictures for different cases of entangled states, while the previous versions
lead to completely different outcomes. This property of the presented scheme is
evidence of its higher generality.Comment: 7 pages, 4 figure
Geometry and Dynamics of a Coupled 4D-2D Quantum Field Theory
Geometric and dynamical aspects of a coupled 4D-2D interacting quantum field
theory - the gauged nonAbelian vortex - are investigated. The fluctuations of
the internal 2D nonAbelian vortex zeromodes excite the massless 4D Yang-Mills
modes and in general give rise to divergent energies. This means that the
well-known 2D CP(N-1) zeromodes associated with a nonAbelian vortex become
nonnormalizable. Moreover, all sorts of global, topological 4D effects such as
the nonAbelian Aharonov-Bohm effect come into play. These topological global
features and the dynamical properties associated with the fluctuation of the 2D
vortex moduli modes are intimately correlated, as shown concretely here in a
U(1) x SU(N) x SU(N) model with scalar fields in a bifundamental representation
of the two SU(N) factor gauge groups.Comment: Latex, 39 pages, 5 figure
Evidence for Efimov quantum states in an ultracold gas of cesium atoms
Systems of three interacting particles are notorious for their complex
physical behavior. A landmark theoretical result in few-body quantum physics is
Efimov's prediction of a universal set of bound trimer states appearing for
three identical bosons with a resonant two-body interaction.
Counterintuitively, these states even exist in the absence of a corresponding
two-body bound state. Since the formulation of Efimov's problem in the context
of nuclear physics 35 years ago, it has attracted great interest in many areas
of physics. However, the observation of Efimov quantum states has remained an
elusive goal. Here we report the observation of an Efimov resonance in an
ultracold gas of cesium atoms. The resonance occurs in the range of large
negative two-body scattering lengths, arising from the coupling of three free
atoms to an Efimov trimer. Experimentally, we observe its signature as a giant
three-body recombination loss when the strength of the two-body interaction is
varied. We also detect a minimum in the recombination loss for positive
scattering lengths, indicating destructive interference of decay pathways. Our
results confirm central theoretical predictions of Efimov physics and represent
a starting point with which to explore the universal properties of resonantly
interacting few-body systems. While Feshbach resonances have provided the key
to control quantum-mechanical interactions on the two-body level, Efimov
resonances connect ultracold matter to the world of few-body quantum phenomena.Comment: 18 pages, 3 figure
Aquaporin-4 and brain edema.
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood. This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma. Experiments using AQP4-null mice provide strong evidence for AQP4 involvement in cerebral water balance. AQP4-null mice are protected from cellular (cytotoxic) brain edema produced by water intoxication, brain ischemia, or meningitis. However, AQP4 deletion aggravates vasogenic (fluid leak) brain edema produced by tumor, cortical freeze, intraparenchymal fluid infusion, or brain abscess. In cytotoxic edema, AQP4 deletion slows the rate of water entry into brain, whereas in vasogenic edema, AQP4 deletion reduces the rate of water outflow from brain parenchyma. AQP4 deletion also worsens obstructive hydrocephalus. Recently, AQP4 was also found to play a major role in processes unrelated to brain edema, including astrocyte migration and neuronal excitability. These findings suggest that modulation of AQP4 expression or function may be beneficial in several cerebral disorders, including hyponatremic brain edema, hydrocephalus, stroke, tumor, infection, epilepsy, and traumatic brain injury
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